Bacterial enzyme inhibitors

Details Bacterial enzyme inhibitors Bacterial enzyme inhibitors

2007-07-10

2007-07-10

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Hydroxamic acids, chalcogen analogs or salts thereof

C562S623000

Reexamination Certificate

active

10497494

ABSTRACT:
Compounds of formula (I) are antibacterial agents: wherein: Z is —N(OH)CH(═O) or —C(═O)NH(OH); R1represents hydrogen, methyl or trifluoromethyl or, except when Z is a radical of formula —N(OH)CH(═O), a hydroxy, halo or amino group; R2, R3and R4independently represents hydrogen or a group R10—(D)n—(ALK)m— wherein R10, D, n, m and ALK are as defined in the claims; or R3and R4taken together with the nitrogen atom to which they are attached form an optionally substituted monocyclic heterocyclic ring containing from 5 to 7 ring atoms, one of which is the nitrogen atom to which R4and R5are attached and the remaining ring atoms being selected from compatible combinations of carbon, oxygen, sulfur and nitrogen

REFERENCES:
patent: 4025622 (1977-05-01), Ogura et al.
patent: WO 99 39704 (1999-08-01), None
patent: WO 99 59568 (1999-11-01), None
Chen et al: “Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor” Biochemistry, American Chemical Society. Easton, PA, US, vol. 39, Feb. 15, 2000, pp. 1256-1262, XP002158085 ISSN: 0006-2960.

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