Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2007-06-26
2007-06-26
Ketter, James (Department: 1636)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C424S093400, C435S252300
Reexamination Certificate
active
09512810
ABSTRACT:
We describe a bacterial delivery system for the delivery of DNA and antigens into cells. We constructed an attenuated bacterial vector which enters mammalian cells and ruptures delivering functional plasmid DNA and antigens into the cell cytoplasm. ThisShigellavector was designed to deliver DNA to colonic surfaces, thus opening the possibility of oral and other mucosal DNA immunization and gene therapy strategies. The attenuatedShigellais also useful as a vaccine for reducing disease symptoms caused byShigella.
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Branstrom Arthur A.
Sadoff Jerald C.
Sizemore Donata R.
Arwine Elizabeth
Harris Charles H.
Ketter James
United States of America as Represented by the Secretary of the
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