Bacterial antigens, antibodies, vaccines and methods of manufact

Details Bacterial antigens, antibodies, vaccines and methods of manufact Bacterial antigens, antibodies, vaccines and methods of manufact

1992-11-24

1994-04-12

Kim, Kay K.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 424 858, 530405, 530411, 435101, 435207, A61K 39385, A61K, A61K, C12P 1904, C07K 1702

Patent

active

053023862

ABSTRACT:
Antigens and vaccines containing purified oligomers (1-50 units) of the repeating pentasaccharide unit of type III Group B Stretococcus (III GBS) polysaccharide capsule. Methods of making the antigen by recovering polysaccharide from cultured III GBS or medium and digesting the polysaccharide with a specific endo-.beta.-galactosidase. Enzymatic cleavage of bacterial polysaccharide to make purified oligomers. A purified trypsin-resistant C surface protein, m.w. about 14,000 and vaccine. Passive immunization using the above vaccines. Immunoassays for GBS immunodeterminants or anti-GBS antibodies.

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