Bacteria that metabolize phenylacetate through mandelate

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

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435142, 435146, 435170, 4352521, 43525234, 4352533, 4352536, C12R 138, C12P 744, C12N 1500

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active

049992929

ABSTRACT:
Bacteria that metabolize phenylacetate along a mandelate-to-cis,cis-muconate pathway are disclosed. Bacteria that express the pathway for metabolizing phenylacetate through a mandelate intermediate can be isolated reproducibly by first selecting bacteria that can utilize both L-phenylalanine and mandelate as the sole carbon source and then blocking alternate pathways for the degradation of L-phenylalanine. The activity of selected enzymes along the mandelate-to-cis,cis-muconate pathway can be blocked in these bacteria to effect the accumulation of selected intermediates.

REFERENCES:
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patent: 4588688 (1986-05-01), Maxwell
patent: 4608338 (1986-08-01), Hsieh
patent: 4654303 (1987-03-01), Hagedorn
patent: 4657863 (1987-04-01), Maxwell et al.
patent: 4673646 (1987-06-01), Hagedorn
patent: 4731328 (1988-03-01), Maxwell
Derwent Abs. 87-109917/16 Hummel et al. (EP 218863) (Apr. 22, 1987).

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