Backbone polysubstituted chelates for forming a metal chelate-pr

Details Backbone polysubstituted chelates for forming a metal chelate-pr Backbone polysubstituted chelates for forming a metal chelate-pr

1986-09-05

1989-05-16

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Isothiocyanate esters

562437, 562443, 548542, C07C16104, C07C 7946, C07C10142, C07D20746

Patent

active

048311758

ABSTRACT:
New polysubstituted diethylenetriaminepentaacetic acid chelates and protein conjugates of the same are described together with the methods of preparing such compounds. A method of delivering radiolabelled compound of the present invention to a target site while minimizing the distribution of the compound to non-targeted organs or tissues is also disclosed.

REFERENCES:
Chang et al., "Bifunctional Chelating Agents: Linking Radiometals to Biological Molecules", Applications of Nuclear and Radiochemistry, pp. 103-114.
McOmie, Protective Groups in Organic Chemistry, 1973, Plenum Press, New York, pp. 44 & 45.

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