Backbone polysubstituted chelates for forming a metal chelate-pr

Details Backbone polysubstituted chelates for forming a metal chelate-pr Backbone polysubstituted chelates for forming a metal chelate-pr

1991-08-22

1993-09-21

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 5303913, 5303915, 5303917, 5303919, 530404, 530405, 530408, 530409, 436545, A61K 4902, A61K 3944, C07K 1528, C07K 1702

Patent

active

052466922

ABSTRACT:
New polysubstituted diethylenetriaminepentaacetic acid chelates and protein conjugates of the same are described together with the methods of preparing such compounds. A method of delivering radiolabelled compound of the present invention to a target site while minimizing the distribution of the compound to non-targeted organs or tissues is also disclosed.

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patent: 4831175 (1989-05-01), Gansow et al.
patent: 5099069, Gansow et al.
Brechbiel et al. (1986) Inorg. Chem. 25:2772-2781.
Chang et al. (1983) in Applications of Nuclear and Radiochemistry (R. M. Lamberecht et al. eds.) Pargamon Press pp. 103-114.
Perkins et al. (1985) Eur J. Med 10:296-301.
Meares et al. (1984a) Anal. Biochem. 142:68-78.
Meares et al. (1984) J. Protein Chem. 3(2):215-228.

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