Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1994-09-02
1997-04-08
Low, Christopher G. F.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 911, 435 9121, 536 221, 935 16, C12P 1934
Patent
active
056187041
ABSTRACT:
Methods for preparing oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. In preferred embodiments, the methods involve radical coupling of 3'- and 5'-substituted or 5'- and 3'-substituted nucleosidic synthons.
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Cook Phillip D.
Sanghvi Yogesh S.
Isis Pharmacueticals, Inc.
Low Christopher G. F.
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