Backbone modified oligonucleotide analogs and preparation thereo

Details Backbone modified oligonucleotide analogs and preparation thereo Backbone modified oligonucleotide analogs and preparation thereo

1998-09-14

2000-02-15

Wilson, James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 221, 536 253, 536 2532, 536 2533, 536 2534, 536 256, 536 2626, 536 267, 536 268, 536 2714, 536 282, C07H 2100, C07H 1900

Patent

active

060254823

ABSTRACT:
Methods for preparing oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. In preferred embodiments, the methods involve reductive coupling of 3'- and 4'- substituted or 4'- and 3'-substituted nucleosidic synthons.

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