Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-03-31
1995-01-31
Rollins, John W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2533, 536 2534, 536 256, 536 231, C07H 100
Patent
active
053860233
ABSTRACT:
Methods for preparing oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. In preferred embodiments, the methods involve reductive coupling of 3'- and 4'-substituted or 4'- and 3'-substituted nucleosidic synthons.
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Cook Phillip D.
Sanghvi Yogesh S.
ISIS Pharmaceuticals
Rollins John W.
Wilson James O.
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