Backbone modified oligonucleotide analogs

Details Backbone modified oligonucleotide analogs Backbone modified oligonucleotide analogs

1991-05-21

1995-01-03

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 256, C07H 100

Patent

active

053788257

ABSTRACT:
Therapeutic oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in wild type oligomers with four atom linking groups forms unique di- and poly- nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.

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