Bacitracin-metal-polyether antibiotic complexes

Details Bacitracin-metal-polyether antibiotic complexes Bacitracin-metal-polyether antibiotic complexes

1985-08-26

1987-09-15

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 25, 514 30, A61K 3702, A61K 3170

Patent

active

046939920

ABSTRACT:
Antibiotic-metal complexes contain bacitracin, a non-toxic, complex-forming metal and a polyether antibiotic are disclosed. The complexes are useful (1) for promoting growth in poultry and mammals, (2) for controlling swine dysentery, (3) modifying rumen fluid by decreasing the acetate to propionate (A/P) ratio, (4) controlling coccidiosis in birds, and (5) purifying bacitracin or a bacitracin-metal salt.

REFERENCES:
patent: 4086345 (1978-04-01), Garzia et al.
patent: 4302450 (1981-11-01), Comai et al.
patent: 4447421 (1984-05-01), Klothen
patent: 4478935 (1984-10-01), Williams et al.
Chem. Abstr., vol. 89, (1978), 40962.
Kirk-Othmer Encyclopedia of Chemical Technology, 2nd Ed., vol. 16, pp. 315-319 and 337-345 (1968).
Polyether Antibiotics, vol. 1, edited by John W. Westley, Marcel Decker, Inc., New York and Bsel, pp. v-xi (1982).
Craig et al., Biochem., 8:2348-2356 (1969).
Merck Index, 10th Ed., Ref. 937 (1983).
Westley, Advances in Applied Microbiology, 22:177-223 (1977).
J. W. Westley et al., J. Am. Chem. Soc., 99:18 (1977).
Froyshov, Chimica Acta, 98:137-139 (1978).
Westley, Polyether Antibiotics, vol. 1 (1982).

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