Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1996-07-15
1998-10-27
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 93461, 424405, 435 6, 435 691, 435 713, 4351721, 4351723, 43525231, 435242, 4353201, 536 237, 536 2371, 536 243, A01N 6300, C12N 1500, C12N 120, C07H 2104
Patent
active
058275150
ABSTRACT:
The present invention relates to a novel sporulation gene isolated from B. thuringiensis, and a DNA segment comprising the nucleic acid sequences encoding the gene and DNA sequences encoding crystal toxin proteins wherein said DNA segment is stably integrated into a B. thuringiensis host by homologous recombination. The invention further relates to a DNA segment wherein the sporulation gene is mutated thereby rendering an oligosporogenic or asporogenic transformed B. thuringiensis as a result of stable integration of the DNA segment into the Bacillus thuringiensis chromosome by homologous recombination.
REFERENCES:
patent: 5277906 (1994-01-01), Zaehner et al.
Adams et al (1994) Molec. Micro 14:381-389 "Elucidation of the mechanism of cryIIIA over production in a mutagenized strain of Bacillus thuringiensis . . .".
Crickmore et al, (1990) Biochem. J 270:133-136 "The Construction of Bacillus thuringiensis strains expressing novel entomocidal .delta.-endotoxin combinations".
Foulger et al. (1991) Molec Micro 5:1363-1373 "Sequential activation of dual promoters by different sigma factors maintains SpoVJ expression . . .".
Lereclus et al. (1995) Bio/Technology 13:67-71 "Overproduction of encapsulated insecticical crystal proteins in a Bacillus thuringiensis . . .".
Cooper Nicole H.
Kalman Sue S.
Reynoso Mitra Shahabi
Yamamoto Takashi
Hobbs Lisa J.
Sandoz Ltd.
Stults Larry W.
Wax Robert A.
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