Bacillus strains for oxidizing hydroxy groups of cholic acid and

Details Bacillus strains for oxidizing hydroxy groups of cholic acid and Bacillus strains for oxidizing hydroxy groups of cholic acid and

1992-06-11

1996-01-02

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a...

435 61, 4352525, 435147, 435832, C12P 3302, C12N 120

Patent

active

054807816

ABSTRACT:
Microorganisms from the genus Bacillus are used to convert chenodeoxycholic acid to 3-alpha-hydroxy-7-keto-5-beta-cholanic acid under aerobic conditions and alkaline pH. Preferred strains are Bacillus FERM BP-4390, Bacillus FERM BP-4391, Bacillus FERM BP-3651, Bacillus FERM BP-3393, Bacillus FERM BP-3398, Bacillus FERM BP-3395 and Bacillus FERM BP-3396. Microorganisms from the genus Bacillus are used to convert cholic acid to 3-alpha-hydroxy-7,12-diketo-5-beta-cholanic acid under aerobic conditions and alkaline pH. Preferred strains are Bacillus FERM BP-3393 and Bacillus FERM BP-3398. Microorganisms from the genus Bacillus are used to convert cholic acid to 3-alpha, 12-alpha-dihydroxy-7-keto-5-cholanic acid under aerobic conditions and alkaline PH. Preferred strains are Bacillus FERM BP-3395 and Bacillus FERM BP-4390.

REFERENCES:
patent: 3801460 (1974-04-01), Stoudt et al.
Ann Microbiology Enzimology 38(2) 1988 pp. 249-256 (see abstract).

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