Bacillus-derived transglutaminase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

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4353201, 435325, 435419, 4352523, 536 232, C12N 910, C12N 1554

Patent

active

059486627

ABSTRACT:
A method for processing a protein, a non-proteinaceous amino acid polymer, or a non-proteinaceous amino acid polymer, or a peptide or derivatives thereof having a crosslinked structure, which entails contacting glutamine and lysine residues in a protein, a non-proteinaceous amino acid polymer, a peptide or derivatives thereof with a transglutaminase obtained from Bacillus subtilus to form intermolecular or intramolecular, crosslinked .epsilon.(.delta.-Glu)-Lys bonds between or in the molecules of the protein, non-proteinaceous amino acid polymer, peptide or derivatives thereof, wherein the transglutaminase has the physicochemical properties described herein.

REFERENCES:
patent: 5736356 (1998-04-01), Sano et al.
Ramanujam et al., Faseb J. 4(7):A2321, 1990.
Brock et al., Biology of Microorganisms, 4th edition, Prentice-Hall, Inc., Englewood Cliffs, NJ, pp. 725-728, 1984.

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