B7-H3 and B7-H4, novel immunoregulatory molecules

Details B7-H3 and B7-H4, novel immunoregulatory molecules B7-H3 and B7-H4, novel immunoregulatory molecules

2011-01-25

2011-01-25

Ouspenski, Ilia (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Reexamination Certificate

active

07875702

ABSTRACT:
The invention provides novel B7-H3 and B7-H4 polypeptides useful for co-stimulating T cells, isolated nucleic acid molecules encoding them, vectors containing the nucleic acid molecules, and cells containing the vectors. Also included are methods of making and using these co-stimulatory polypeptides.

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Skolnick et al., Trends in Biotech., 18(1):34-39, 2000.
Coyle et al., Nature Immunol., 2:203-209, 2001.
Metzler et al., Nature Structural Biol., 4:527-531, 1997.

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