Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-04-18
2006-04-18
Gambel, Phillip (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S387300, C530S395000, C424S134100, C424S184100, C424S185100, C424S192100, C424S278100
Reexamination Certificate
active
07030219
ABSTRACT:
A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and methods are disclosed for inducing potent T cell mediated responses that can be harnessed for anti-tumor and anti-viral immunity.
REFERENCES:
patent: 5521288 (1996-05-01), Linsley et al.
patent: 5861310 (1999-01-01), Freeman et al.
patent: 5942607 (1999-08-01), Freeman et al.
patent: 2002/0095024 (2002-07-01), Mikesell et al.
patent: 2002/0106730 (2002-08-01), Coyle et al.
patent: 2002/0107363 (2002-08-01), Fox et al.
patent: 2002/0164600 (2002-11-01), Freeman et al.
patent: 1074617 (2000-10-01), None
patent: WO 92/00092 (1992-01-01), None
patent: WO 95/05464 (1995-02-01), None
patent: WO 97/24447 (1997-07-01), None
patent: WO 00/55375 (2000-09-01), None
patent: WO 00/61612 (2000-10-01), None
patent: WO 01/34629 (2001-05-01), None
patent: WO 02/02587 (2002-01-01), None
Metzler et al. Nature Structural Biol. 1997; 4:527-531.
Coyle et al. Nature Immunol. 2:203-209 2001.
Peach et al. J. Biol. Chem. 1995; 270:21181-21187.
Henry, H., “Structure and Evolution Of the Extended B7 Family”, vol. 20, Immunology Today, No. 6, Jun. 1999, pp. 285-288.
Freeman, Gordon J., Cloning of B7-2: A CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation, vol. 262, Science, Nov. 1993, pp. 909-911.
Freeman, Gordon J., “B7, A New Member of the Ig Superfamily With Unique Expression On Activated And Neoplastic B Cells”. vol. 143, No. 8, Oct. 1989, The Journal of Immunology, pp. 2714-2722.
Razi-Wolf, Ziba, “Expression And Function of the Murine B7 Antigen, The Major Costimulatory Molecule Expressed by Peritoneal Exudate Cells”, vol. 89, Proc. Natl. Acad. Sci, May 1992, pp. 4210-4214.
Linsey, Peter S., T-Cell Antigen CD28 Mediates Adhesion With B Cells By Interacting With Activation Antigen B7/BB-1, Vol. 87, Proc. Natl. Acad. Sci., Jul. 1990, pp. 5031-5035.
Lenschow, D., “Expression And Functional Significance Of an Additional Ligand for CTLA-4”, vol. 90. Proc. Natl. Avad. Sci., Dec. 1993, pp. 11054-11058.
Gimmi, C. et al., “B-Cell Surface Antigen B7 Provides a Costimulatory Signal That Induces T Cells to Proliferate and Secrete Interleukin 2”, vol. 88, Proc. Natl. Acad. Sci., Aug. 1991, pp. 6575-6579.
Linsley, P, et al., Binding Of the B Cell Activation Antigen B7 to CD28 Costimulates T Cell Proliferation and Interleukin 2 mRNA Accumulation, vol. 173, J. Exp. Med., Mar. 1991, pp. 721-730.
Freeman, G. et al., Structure, Expression, and T Cell Costimulatory Activity of the Murine Homologue Of The Human B Lymphocyte Activation Antigen B7, vol. 174, J. Exp. Med., Sep. 1991, pp. 625-631.
Freeman, G. et al., Engagement Of the PD-1 Immunoinhibitory Receptor By a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation, vol. 192, J. Exp. Med., No. 7, Oct. 2000, pp. 1027-1034.
Henry, J. et al., “Cloning, Structural Analysis, and Mapping Of the B30 and B7 Multigen Families to the Major Histocompatibility Complex (MHC) and Other Chromosomal Regions”, vol. 46, Immunogenetics, 1997, pp. 383-395.
Tazi-Ahnini et al. ,Cloning, Localization, and Structure of New Members Of The Butyrophilin Gene Family In The Juxta-telomeric Region of the Major Histocompatibility Complex, vol. 47, Immunogenetics, 1997, pp. 55-63.
Schwartz, R., Costimulation of T Lymphocytes: The Role Of CD28, CTLA-4, and B7/BB1 In Interleukin-2 Production and Immunotherapy, vol. 71, Cell, Dec. 1992, pp. 1065-1068.
Chen L., et al., “Costimulation Of Antitumor Immunity By the B7 Counterreceptor For the T Lymphocyte Molecules CD28 and CTLA-4”, vol. 71, Cell, Dec. 1992, pp. 1093-1102.
Dong, H., et al., “B7-H1, A Third Member Of The B7 Family, Co-Stimulates T-Cell Proliferation and Interleukin-10 Secretion”, vol. 5, No. 12. Nature.Medicine, Dec. 1999, pp. 1365-1369.
Wang, S. et al., Costimulation Of T Cells By B7-H2, a B7-Like Molecule That Binds ICOS, vol. 96, No. 8, Immunobiology-Blood, Oct. 2000, pps. 2808-2813.
Swallow, M. et al., B7h, a Novel Costimulatory Homolog B B7.1 and B7.2, Is Induced by TNF-alpha, vol. 11, Immunity, Oct. 1999, pp. 423-432.
Yoshinaga, S., et al., T-Cell Co-Stimulation Through ByRP-1 and ICOS. vol. 402, Nature, Dec. 1999, pp. 827-832.
Tseng S. et al., “B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells,”J. Exper. Med.,vol. 193, No. 7, (Apr. 2, 2001), pp. 839-845.
Database EM_MUS [Omline]EMBL;Accession No.: AF142780 (Jun. 1, 1999).
Database EM_HUM [Online]EMBL; Accession No.:AK001872 (Feb. 22, 2000).
Chen L. et al., “Costimulation of Antitumor Immunity by the B7 Counterreceptor of the T Lymphocyte Molecules CD28 and CTLA-4,”Cell,vol. 71, (Dec. 24.1992), pp. 1093-1102.
Gerstmayer B. et al/. “Costimulation of T-cell proliferation by a chimeric B7-antibody fusion protein,”Cancer Immunology Immunotherapy,vol. 45, No. 3-4, (Nov. 1997), pp. 156-158.
Henry, J. et al., “Structure and evolution of the extended B7 family,”Immunology Today,vol. 402, (Dec. 16 1999) pp. 827-832.
Yoshinga S.K. et al., “T-cell co-stimulation through B7RP-1 and ICOS,”Naturevol. 402, (Dec. 16 1999) pp. 827-832.
Townsend S.E. et al, Tumor Rejection After Direct Costimulation of CD8+T Cells by B7-Transfected Melanoma Cells,Science,vol. 259, (Jan. 15, 1993), pp. 368-370.
Gorski Kevin S.
Pardoll Drew M.
Tseng Su-Yi
Tsuchiya Haruo
Banner & Witcoff LLP
Gambel Phillip
Johns Hopkins University
Ouspenski Ilia
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