Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1996-01-12
1999-03-02
LeGuyader, John L.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435 6, 435 9131, 4351723, 4353201, 435325, 536 231, 536 232, 536 245, C12Q 168, C12N 508, C70H 2102
Patent
active
058770216
ABSTRACT:
Nucleic acid molecule which blocks synthesis and/or expression of an mRNA encoding B7-1.
REFERENCES:
patent: 4987071 (1991-01-01), Cech et al.
patent: 5359051 (1994-10-01), Cook et al.
Stull et al. Pharm. Res. 12: 465-483 (1995).
Gewirtz et al. PNAS 93:3161-3163 (1996).
Azuma et al., "B70 antigen is a second ligand for CTLA-4 and CD28," Nature 366:76-79 (1993).
Blazer et al., "In Vivo Blockade of CD28/CTLA4: B7/BB1 Interaction With CTLA4-Ig Reduces Lethal Murine Graft-Versus-Host Disease Across the Major Histocompatibility Complex Barrier in Mice," Blood 83:3815-3825 (1994).
Boussiotis et al., "Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation," Proc. Natl. Acad. Sci. USA 90:11059-11063 (1993).
Caine, "Immunosuppression for Organ Grafting," Transplantation Proceedings 24:1260-1262 (1992).
Carlson et al., "Immunomodulating Drugs," Ann. N.Y. Acad. Sci. 685:86-113 (1993).
Carter, "Adeno-Associated Virus Vectors," Curr Opi, Biotech. 3:533-539 (1992).
Chen et al., "Multitarget-Ribozyme Directed to Cleave at up to Nine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1 Replication-Potential Effectiveness Against Most Presently Sequenced HIV-1 Isolates," Nucleic Acids Research 20:4581-4589 (1992).
Chowrira et al., "In Vitro and in Vivo Comparison of Hammerhead, Hairpin, and Hepatitis Delta Virus Self-Processing Ribozyme Cassettes," J. Biol. Chem. 269:25856-25864 (1994).
Chowrira and Burke, "Extensive Phosphorothioate Substitution Yields Highly Active and Nuclease-Resistant Hairpin Ribozymes," Nucleic Acids Res. 20:2835-2840 (1992).
Clark and Ledbetter, "How B and T Cells Talk to Each Other," Nature 367:425-428 (1994).
Cohen, "New Protein Steals the Show As `Costimulator` of T Cells," Science 262:844 (1993).
Collins and Olive, "Reaction Conditions and Kinetics of Self-Cleavage of a Ribozyme Derived From Neuropora VS RNA," Biochemistry 32:2795-2799 (1993).
Dropulic et al., "Functional Characterization of U5 Ribozyme: Intercellular Suppression of Human Immunodeficiency Virus Type 1 Expression," Journal of Virology 66:1432-1441 (1992).
Duval-Valentin, "Specific Inhibition of transcription by triple helix-forming oligonucleotides," Proc. Natl. Acad. Sci. USA 89:504 (1992).
Egholm et al., "PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules," Nature 365:566-568 (1993).
Elroy-Stein and Moss, "Cytoplasmic Expression System Based on Constitutive Synthesis of Bacteriophage T7 RNA Polymerase in Mammalian Cells," Proc. Natl. Acad. Sci. USA 87:6743-6747 (1990).
Finck et al., "Treatment of Murine Lupus with CTLA4Ig," Science 265:1225-1227 (1994).
Fodor et al., "Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogenic hyperacute organ rejection," Proc. Natl. Acad. Sci. USA 91:11153-11157 (1994).
Foy et al., "In Vivo CD40-gp39 Interactions Are Essential for Thymus-dependent Humoral Immunity. II. Prolonged Suppression of the Humoral Immune Response by an Antibody to the Ligand for CD40, gp39," J. Exp. Med. 178:1567-1575 (1993).
Freeman et al., "Uncovering of Functional Alternative CTLA-4 Counter-Receptor in B7-Deficient Mice," Science 262:907-909 (1993).
Fulehian et al., "Cyclosporin A Inhibits CD40 Ligand Expression in T Lymphocytes," J. Clin. Invest. 93:1315-1320 (1994).
Gao and Huang, "Cytoplasmic Expression of a Reporter Gene by Co-Delivery of T7 RNA Polymerase and T7 Promoter Sequence with Cationic Liposomes," Nucleic Acids Res. 21:2867-2872 (1993).
Guerrier-Takada et al., "The RNA Moiety of Ribonuclease P Is the Catalytic Subunit of the Enzyme," Cell 35:849-857 (1983).
Hampel et al., "`Hairpin` Catalytic RNA Model: Evidence for Helics and Sequence Requirement for Substrate RNA," Nucleic Acids Research 18:299-304 (1990).
Hampel and Tritz, "RNA Catalytic Properties of the Minimum (-)sTRSV Sequence," Biochemistry 28:4929-4933 (1989).
Harding et al., "CD28-mediated signalling co-stimulates murine T cells and prevents induction of energy in T-cell clones," Nature 356:607-609 (1992).
Haseloff and Gerlach, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities," Nature 334:585-591 (1988).
Hathcock et al., "Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation," Science 262:905-907 (1993).
Hathcock et al., "Comparative Analysis of B7-1 and B7-2 Costimulatory Ligands: Expression and Function," J. Exp. Med. 180:631-640 (1994).
Hertel et al., "Numbering System for the Hammerhead," Nucleic Acids Res. 20:3252 (1992).
Jaeger et al., "Improved Predictions of Secondary Structures for RNA," Proc. Natl. Acad. Sci. USA 86:7706-7710 (1989).
Janeway and Bottomly, "Signals and Signs for Lymphocyte Responses," Cell 76:275-285 (1994).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1989).
Jenkins et al., "Molecular events in the induction of a nonresponsive state in interleukin 2-producig helper T-lymphocyte clones," Proc. Natl. Acad. Sci. USA 84:5409-5413 (1987).
Kashani-Sabet et al., "Reversal of the Malignant Phenotype by an Anti-ras Ribozyme," Antisense Research & Development 2:3-15 (1992).
Kemeny and Diaz-Sanchez, "Can persistent IgE responses be suppressed?" Clin. Exp. Immunol. 82:423-426 (1990).
Koulova et al., "The CD28 Ligand B7/BB1 Provides Costimulatory Signal for Alloactivation of CD.sup.+ T Cells," J. Exp. Med. 173:759-762 (1991).
Kuchroo et al., "B7-1 and B7-2 Costimulatory Molecules Activate Differentially the Th1/Th2 Developmental Pathways: Application to Autoimmune Disease Therapy," Cell 80:707-718 (1995).
L'Huillier et al., "Cytoplasmic Delivery of Ribozymes Leads to Efficient Reduction in .alpha.-Lactalbumin mRNA Levels in C1271 Mouse," Embo J. 11:4411-4418 (1992).
Lenschow et al., "Expression and functional significance of an additional ligand for CTLA-4," Proc. Natl. Acad. Sci. USA 90:11054-11058 (1993).
Lenschow et al., "Long-Term Survival of Xenogenic Pancreatic Islet Grafts Induced by CTLA41g," Science 257:789-792 (1992).
Lieber et al., "Stable High-Level Gene Expression in Mammalian Cells by T7 Phage RNA Polymerase," Methods Enzymol. 217:47-66 (1993).
Linsley et al., "Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule," Science 257:792-795 (1992).
Linsley et al., "Binding of the B Cell Activation Antigen B7 to CD28 Costimulates T Cell Proliferation and Interleukin 2 mRNA Accumulation," J. Exp. Med. 173:721-730 (1991).
Linsley et al., "Human B7-1 (CD80) and B7-2 (CD86) Bind with Similar Avidities but Distinct Kinetics to CD28 and CTLA-4 Receptors," Immunity 1:793-801 (1994).
Lisziewicz et al., "Inhibition of Human Immunodeficiency Virus Type 1 Replication by Regulated Expression of a Polymeric Tat Activation Response RNA Decoy as a Strategy for Gene Therapy in AIDS," Proc. Natl. Acad. Sci. U.S.A. 90:8000-8004 (1993).
Marshall et al., "The Molecular Basis for T Cell Help in Humoral Immunity: CD40 and Its Ligand, gp39," J. Clin. Immun. 13:165-174 (1993).
Milligan and Uhlenbeck, "Synthesis of Small RNAs Using T7 RNA Polymerase," Methods Enzymol. 180:51-62 (1989).
Nowak, "Xenotransplants Set to Resume," Science 266:1148-1151 (1994).
Ohkawa et al., "Activities of HIV-RNA Targeted Ribozymes Transcribed From a `Shot-Gun` Type Ribozyme-trimming Plasmid," Nucleic Acids Symp. Ser. 27:15-16 (1992).
Ojwang et al., "Inhibition of Human Immunodeficiency Virus Type 1 Expression by a Hairpin Ribozyme," Proc. Natl. Acad. Sci. USA 89:10802-10806 (1992).
Perreault et al., "Mixed Deoxyribo-and Ribo-Oligonucleotides with Catalytic Acitvity," Nature 344:565-567 (1990).
Perrotta and Been, "Cleavage of Oligoribonucleotides by a Ribozyme Derived from the Hepatitis .delta. Virus RNA Sequence," Biochemistry 31:16-21 (1992).
Pieken et all, "Kinetic Characterization of Ribonuclease-Resistant 2'-Modified Hammerhead Ribozymes," Science 253:314-317 (1991).
Pretolani et al., "Cytokines-Eosinophil Interactions in Experimental Allergy," Ann. N.Y. Acad. Sci. 725:247-258 (1994).
Rossi et al, "Ribozymes as Anti-HIVI-1 Therapeutic Agents: Principles
Jarvis Thale
McSwiggen James
Stinchcomb Dan T.
LeGuyader John L.
Ribozyme Pharmaceuticals Inc.
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