B.sub.2 adrenegic agonists and use thereof in the treatment of g

Details B.sub.2 adrenegic agonists and use thereof in the treatment of g B.sub.2 adrenegic agonists and use thereof in the treatment of g

1993-04-19

1994-05-24

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514546, 560 46, 560139, A61K 3122, A61K 3124, C07C 6903, C07C 69757

Patent

active

053149165

ABSTRACT:
Compounds having beta-2 adrenergic agonist activity and the use of these compounds in controlling intraocular pressure are disclosed. The compounds are believed to be useful in controlling intraocular pressure by increasing the outflow of aqueous humor. The compounds are considered to be less likely to cause cardiovascular side effects and various other side effects associated with stimulation of beta-1 receptors, relative to epinephrine.

REFERENCES:
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patent: 4826879 (1989-05-01), Yamamoto et al.
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Delgado, et al., "Synthesis and Conformational Analysis of 2-Amino-1,2,3,4-Tetrahydro-1-Naphthalenols," Can J. Chem., vol. 66, pp. 517-527 (1988).
Motohashi, et al., "Crystal Structure of (.+-.)-trans-2-Cyclobutylamino-5,6-dihydroxy-1,2,3,4-tetrahydro-1-naphthal enol Hydrobromide", Chem. Pharm. Bull., vol. 28, No. 12, pp. 3656-3661 (1980).
Chemical Abstract 84(15): 105281e, (1975), Sugihara, et al.
Chemical Abstract 94(10): 75107q, (1980), Motohashi, et al.

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