B. pertussis vaccine production using carbodiimides

Details B. pertussis vaccine production using carbodiimides B. pertussis vaccine production using carbodiimides

1986-05-21

1988-11-29

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 435 68, 435822, 530405, 530409, 530413, A61K 3910

Patent

active

047880589

ABSTRACT:
The present invention provides a method of preparing a substantially non-toxic immunogenic preparation of pertussis toxic comprising treatment of pertussis toxin with a carbodiimide. The preparation may be used for vaccination against whooping cough as well as making vaccines for use in immunization against whooping cough. Desirably the pertussis toxin is treated in the form of an intimate admixture with filamentous.

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patent: 4687738 (1987-08-01), Ginnaga et al.
Pharmacology & Therapeutics, 19, 1-53 (1983), Wardlaw et al.

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