B-lymphocyte stimulator binding polypeptides and methods...

Details B-lymphocyte stimulator binding polypeptides and methods... B-lymphocyte stimulator binding polypeptides and methods...

2010-02-05

2011-11-22

Duffy, Patricia A (Department: 1645)

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

C530S326000

Reexamination Certificate

active

08062906

ABSTRACT:
Binding polypeptides that specifically bind B lymphocyte stimulator protein or B lymphocyte stimulator-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate function of B lymphocyte stimulator or B lymphocyte stimulator receptor, comprising B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate B lymphocyte stimulator function or B lymphocyte stimulator receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator.

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