Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Reexamination Certificate
2006-03-28
2006-03-28
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
C424S060000, C424S400000, C424S401000
Reexamination Certificate
active
07018623
ABSTRACT:
The present invention relates generally to the use of vitamin B12 (cobalamin or cyanocobalamin) alone or in combination with other photoprotective agents, including specifically other vitamins such as vitamin B9 (folic acid or folate) and vitamin B3 (niacin or niacinamide), or any chemical derivative of these vitamins and their salts, as a filter to protect cells against the damaging effects of ultraviolet (UV) light. The invention is, in one aspect, a method of reducing the rate of UV damage to cells exposed to a UV light source, by treating the cells with the vitamin composition, either alone or in combination with other photoprotective agents. Other aspects of the invention are compositions comprising effective amounts of vitamin B12 alone or in combination with other photoprotective agents including vitamin B9 and vitamin B3 and a pharmaceutically-acceptable carrier, that are useful in protecting cells, particularly skin cells, against the burning, genotoxic (mutagenic and carcinogenic), immunosuppressive and photoaging effects of UV light, especially sunlight. The invention has application as a UV light filter in oral preparations including tablets and drinks, topical creams, lotions, sprays, wipes and cosmetics. The invention also has application as a medicinal treatment for dermatological conditions caused by exposure to sunlight, such as actinic keratoses, photodermatitis, photo-induced (discoid) lupus erythematosus and the photosensitizing effects of a variety of drugs used commonly in clinical practice (e.g. certain antihistamines, ACE inhibitors, and antibiotics such as tetracycline).
REFERENCES:
patent: 6251878 (2001-06-01), Strickland et al.
Article (on-line) Jun. 10, 2000 ‘Company Launches Sunburn Pill’Press Releasewww.pressbox.co.uk.
Tenth International Symposium; Chemistry and Biology of Pteridines and Folates; Orange Beach Alabama; Mar. 21-26, 1993; Final Program and Abstract Book: B12—B.J. Barclay et al.; “Effect Of Chromosome Position On Amplification Of The DHFR Gene In Saccharomyces Cerevisiae” B-13—B.J. Barclay et al.; “A DHFR Mutant Of Saccharomyces Cerevisiae Is Defective In DNA Repair” B-14—T. Huang et al.; Phenotypic Suppressors Of A Dihydrofolate Reductase Mutant Of Saccharomyces Cerevisiae B-15—M.G. Nagel et al.; “Dihydrofolate Reductase Is Not The Target Of Trimethoprim In Saccharomyces Cerevisiae”.
Dodson Shelley A.
Nields & Lemack
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