B.beta.-Pyrimidino-aminomethyl-10.alpha.-ergoline and 10.alpha.-

Details B.beta.-Pyrimidino-aminomethyl-10.alpha.-ergoline and 10.alpha.- B.beta.-Pyrimidino-aminomethyl-10.alpha.-ergoline and 10.alpha.-

1974-07-31

1976-05-18

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602564N, 424251, C07D45702

Patent

active

039577856

ABSTRACT:
Novel 8.beta.-pyrimidino-aminomethyl-10.alpha.-ergoline and 10.alpha.-methoxyergoline derivatives which possess a high and prolonged adrenolytic activity and a low toxicity, and some of which also possess hypotensive and analgesic activity are prepared by reacting a pyrimidine anion with an ergoline derivative in an aprotic solvent.

REFERENCES:
patent: 2449908 (1948-09-01), Prevost
patent: 2484606 (1949-10-01), Braker
patent: 3557118 (1971-01-01), Arcamone et al.
patent: 3646046 (1972-02-01), Arcamone et al.
patent: 3681349 (1972-08-01), Schwan et al.
Sidgwick, Organic Chemistry of Nitrogen, Oxford Press, 1937, pp. 297-298.

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