Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Bacteria or actinomycetales
Reexamination Certificate
2011-06-07
2011-06-07
Devi, S. (Department: 1645)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Bacteria or actinomycetales
C424S093200, C424S184100, C424S200100, C424S234100, C435S485000, C435S483000, C435S252310
Reexamination Certificate
active
07955596
ABSTRACT:
The present invention pertains to the discovery thatB. anthracispossesses a luxS gene that encodes a functional LuxS polypeptide, and thatB. anthracissynthesizes a functional AI-2 quorum-sensing molecule. The invention provides mutantB. anthracisbacteria lacking the function of the luxS gene, which do not produce a functional AI-2 molecule and have growth defects compared to wild-typeB. anthracis. The invention also concerns methods for inhibiting the growth ofB. anthracis, or for preventing or treatingB. anthracisinfection, by inhibiting the activity of theB. anthracisLuxS polypeptide, or by exposure of theB. anthracisto furanone. In particular, the invention concerns the use of furanone, a compound that inhibits AI-2-mediated quorum-sensing, to inhibit the growth ofB. anthracis, to inhibitB. anthracistoxin production, particularly that of protective antigen, and to prevent or treatB. anthracisinfection. The invention also provides methods to preventB. anthracisinfection, or enhance an immune response toB. anthracisinfection, by administering a vaccine comprising aB. anthraciscell in which the luxS gene is mutated.
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Blaser Martin J.
Jones Marcus B.
Ren Dacheng
Wood Thomas
Devi S.
Fish & Richardson P.C.
New York University
University of Connecticut
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