Azulenyl nitrone spin trapping agents, methods of making and usi

Details Azulenyl nitrone spin trapping agents, methods of making and usi Azulenyl nitrone spin trapping agents, methods of making and usi

1997-09-04

2000-07-04

O'Sullivan, Peter

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514 12, 514 21, 514114, 514297, 514510, 514519, 514553, 514557, 514561, 514579, 514613, 514640, 514644, 514645, 514676, 514704, 514740, 530358, 5303871, 546104, 546106, A61K 31435, A61K 31275, A61K 31165, A61K 3115

Patent

active

060839880

ABSTRACT:
The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping free radical species and find use as efficient antioxidants in physicochemical and biological systems. Accordingly, the invention also relates to spin adducts formed from the combination of azulenyl nitrones with free radicals. The compounds of the present invention are readily prepared from available starting materials and find further use in assays and in a number of diagnostic, prophylactic and therapeutic applications, including but not limited to the alleviation, modulation and inhibition of the negative effects of carbon-centered or oxygen-centered radical species and other products of oxidation. Moreover, the combination adducts may be calorimetrically detected and, optionally, isolated and characterized to obtain valuable information (e.g., structural and the like) about the original reactive free radical species.

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