Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1991-06-17
1995-01-10
Ceperley, Mary E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
435 725, 435188, 436520, 436528, 436532, 436533, 436545, 436546, 530363, 530380, 530404, 530405, 530406, 530807, C07K 1300, C12N 996, G01N 33533, G01N 33534
Patent
active
053808258
ABSTRACT:
This invention relates to a method for the immunoassay of AZT (3'-azido-3'-deoxythymidine), also known as zidovudine, in biological fluids such as serum, semen, plasma and urine, as well as other body fluids. The invention also includes (1) various novel analogs of AZT useful in preparing immunogens for antibodies to AZT and in preparing labeled AZT, (2) immunogens for antibodies to AZT, (3) monoclonal and polyclonal antibodies to AZT, (4) labeled AZT analogs and (5) diagnostic test kits for the immunoassay.
REFERENCES:
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4824941 (1989-04-01), Gordon et al.
B. Erlanger, Pharmacological Reviews, vol. 25, No. 2, pp. 271-280 (1973).
R. Schall et al., Clinical Chemistry, vol. 27, No. 7, pp. 1157-1164 (1981).
Blum, M. Robert, Ph.D., et al., "Pharmacokinetics and Bioavailability of Zidovudine in Humans", The American Journal of Medicine, vol. 85 (suppl 2A), Aug. 29, 1988, pp. 189-194.
Furman, Phillip A., et al., "Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus* reverse transcriptase", Proceedings of the National Academy of Sciences, U.S.A., vol. 83, Nov. 1986, pp. 8333-8337.
Glinski, Ronald P., et al., "The Synthesis of Phosphorylated 3'-Amino-3'-deoxythymidine and 5'-Amino-5'-deoxythymidine", Chemical Communicatins, 1970, pp. 915-916.
Glinski, Ronald P., et al., "Nucleotide Synthesis. IV..sup.1 Phosphorylated 3'-Amino-3'-deoxythymidine and 5'-Amino-5'-deoxythymidine and Derivatives.sup.2,3 ", J. Org. Chem., vol. 38, No. 25, 1973, pp. 4299-4305.
Good, S. S. et al., "Biotransformation in Various Species and in Humans of 3'-Azido-3'-Deoxythmidine, A Potential Agent for the Treatment of Aids", Abstract No. 1690, Federation Proceedings, Federation of American Societies for Experimental Biology, vol. 45, No. 3, Mar. 1, 1986, p. 444.
Good, Steven S., et al., "Simultaneous Quantification of Zidovudine and Its Glucuronide in Serum by High-Performance Liquid Chromatography", Journal of Chromatography, 431 (1988) pp. 123-133.
Horwitz, Jerome P., et al., "Nucleosides. v. The Monomesylates of 1-(2'-Deoxy-.beta.-D-lyxofuranosyl)thymine.sup.1,2 ", Journal of Organic Chemistry, vol. 29, Jul., 1964, pp. 2076-2078.
Imazawa, M. and F. Eckstein, "Synthesis of 3'-Azido-2',3'-dideoxyribofuranosylpurines", Journal of Organic Chemistry, vol. 43, No. 15, 1978, pp. 3044-3048.
Incstar Corporation, "ZDV-TRAC.TM. RIA: AZT, Retrovir, Zidovudine", Instar Science Technology and Research, Package Insert, Part #11688, Revised Jun., 1988.
Krasny, H. C. and S. S. Good, "Pharmacokinetics and Metabolism of Azidothymidine in the Dog", Abstract No. 311, Federation Proceedings, Federation of American Societies for Experimental Biology, vol. 45, No. 3, Mar. 1, 1986, p. 207.
Krodstad, D. J., et al., "Fluorescence Polarization Immunoassay for AZT", Abstract No. 1464, Program and Abstracts of the Twenty-Eighth Interscience Conference on Antimicrobial Agents and Chemotherapy, ASM News, vol. 54, No. 8, 1988, p. 371.
Matsuda, Akira, et al., "Nucleosides. 115. Reaction of 3'-O-Mesylthymidine. Formation of 1-(3-Azido-2,3-dideoxy-.beta.-D-threo-pentofuranosyl)thymine and Its Conversion into 6,3'-Imino-1-(2,3-dideoxy-.beta.-D-threo-pentofuranosyl)thymine.sup.1 ", Journal of Organics Chemistry, vol. 45, No. 16, 1980, pp. 3274-3278.
Quinn, Richard P., et al., "A Radioimmunoassay for Azidothymidine (AZT) Using a High Specific Activity Tritiated Antigen", Abstract No. 1465, Program and Abstracts of the Twenty-Eighth Interscience Conference on Antimicrobial Agents and Chemotherapy, ASM News, vol. 54, No. 8, 1988, p. 371.
Murray Dennis M.
Stenglein Kenneth J.
Ceperley Mary E.
Sigma Chemical Company
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