Azonafide derived tumor and cancer targeting compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S076000, C544S361000, C514S002600, C514S253030

Reexamination Certificate

active

08008316

ABSTRACT:
An azonafide-based compound of Formula I, a composition comprising the compound, and a method of using the compound to deliver a cytotoxic azonafide derivative to a cell, as well as related compounds and methods for the use thereof to pre-pare an azonafide-based compound of Formula I.

REFERENCES:
patent: 5635506 (1997-06-01), Alberts et al.
patent: 5703089 (1997-12-01), Braña et al.
patent: WO 92/00281 (1992-01-01), None
patent: WO 03/072754 (2003-09-01), None
patent: WO 2006/060533 (2006-06-01), None
Czerwinski et al., “Cytotoxic agents directed to peptide hormone receptors: Defining the requirements for a successful drug,”PNAS, 95, 11520-11525 (1998).
Dorr et al., “Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators,”Anticancer Drugs, 12 (3), 213-220 (2001).
Dyba et al., “Small Molecule Toxins Targeting Tumor Receptors,”Curr. Pharm. Des., 10, 2311-2334 (2004).
Jaracz et al, “Recent advances in tumor-targeting anticancer drug conjugates,”Bioorg. Med. Chem., 13, 5043-54 (2005).
Langer, “New Methods of Drug Delivery,”Science, 249, 1527-1533 (1990).
Sami et al., “2-substituted 1,2-Dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. A new class of antitumor agent,”J. Med. Chem., 36, 765-770 (1993).
Sami et al., “Amino-Substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones. Synthesis, antitumor activity, and quantitative structure—activity relationship,”J. Med. Chem., 38, 983-993 (1995).
Sami et al., “6- and 7-substituted 2-[2'-(Dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships,”J. Med. Chem., 39, 1609-1618 (1996).
Sami et al., “2-[2'-(Dimethylamino)ethyl]-1,2-dihydro- 3H-dibenz[de,h]isoquinoline-1,3-diones with substituents at positions 4, 8, 9, 10, and 11. Synthesis, antitumor activity, and quantitative structure-activity relationships,”J. Med. Chem., 39, 4978-87 (1996).
Sami et al., “Analogues of amonafide and azonafide with novel ring systems,”J. Med. Chem., 43, 3067-3073 (2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Azonafide derived tumor and cancer targeting compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azonafide derived tumor and cancer targeting compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azonafide derived tumor and cancer targeting compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2648863

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.