Azolo triazines and pyrimidines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544281, C07D48704, A61K 31495

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active

061368091

ABSTRACT:
Corticotropin releasing factor (CRF) antagonists of formula I or II: ##STR1## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.

REFERENCES:
patent: 3910907 (1975-10-01), O'Brien et al.
patent: 3920652 (1975-11-01), Springer et al.
patent: 3995039 (1976-11-01), Rooney et al.
patent: 4021556 (1977-05-01), Springer et al.
patent: 4567263 (1986-01-01), Eicken et al.
patent: 4892576 (1990-01-01), Kruger et al.
patent: 4990647 (1991-02-01), Himmler et al.
patent: 4997940 (1991-03-01), Vinogradoff et al.
patent: 5089499 (1992-02-01), Barker et al.
patent: 5137887 (1992-08-01), Hashimoto et al.
patent: 5397774 (1995-03-01), Nugent et al.
patent: 5428044 (1995-06-01), Bantick et al.
patent: 5463071 (1995-10-01), Himmelsbach et al.
patent: 5464847 (1995-11-01), Courtemanche et al.
patent: 5484760 (1996-01-01), Bussler et al.
patent: 5486531 (1996-01-01), Schonafinger et al.
patent: 5723608 (1998-03-01), Yuan
Corticotropin Releasing Factor: Basic and Clinical Studies of a Neuropeptide (De Souza, Nemeroff) pp. 221-224 (1990).
Comprehensive Organic Synthesis (Trost, Fleming) 3:481-520 (1991).
Comprehensive Organic Synthesis (Trost, Fleming) 7:762-769 (1991).
Remington's Pharmaceutical Sciences (Gennaro, ed.) 17.sup.th ed. P. 1418-1419 (1985).
Arch. Pharm. (Weinheim) 320, 487-491 (1987).
Psychopharmacology (Britton, Lee, Koob) 94:306-311 (1988).
Life Sciences (Britton, Koob, Rivier, Vale) 31:363-367 (1982).
Bull. Soc. Chim. Belg. (Maquestiau, Taghret, Eynde) vol. 101/No. 2/1992.
J. Med. Chem. (Senga, et al.) 25:243-249 (1982).
Synapse (Battaglia, Webster, De Souza) 1:572-581 (1987).
Science (Nemeroff, et al.) 226:1342 (1984).
Brain Research Reviews (Dunn, Berridge) 15:71-100 (1990).
Proc. Natl. Acad. Sci. (Rivier, Spiess, Vale) 80:4851-4855 (1983).
Recent Progress in Hormone Research (Vale, et al.) 39:245-271 (1983).
Journal of Neuroscience (De Souza, et al.) vol. 5, No. 12, pp. 3189-3203 (1985).
Perspectives on Behavioral Medicine (Koob) 2:39-52 (1985).
Biol. Psychiatry (France, et al.) 23:86-88 (1988).
Hormones and Behavior (Berridge, Dunn) 21:393-401 (1987).
Hospital Practice (De Souza) pp. 59-71 (1988).
Arch. Gen Psychiatry (Sapolsky) 46:1047-1051 (1989).
Psychopharmacology (Britton, et al.) 86:170-174 (1985).
Biol. Psychiatry (Arato, et al.) 25:355-359 (1989).
Regulatory Peptides (Berridge, Dunn) 16:83-93 (1986).
Neuropsychopharmacology (Grigoriadis, et al.) vol. 2, No. 1, pp. 53-60 (1989).
Psychopharmacology (Swerdlow, Geyer, Vale, Koob) 88:147-152 (1986).
Am. J. Psychiatry (Banki, et al.) 144:873-877 (1987).
Arch. Gen. Psychiatry (Nemeroff, et al.) 45:577-579 (1988).
New Eng. J. Med. (Gold, et al.) vol. 314, No. 21, pp. 1329-1335 (1986).
Life Sciences (Morley, et al.) 41:527-544 (1987).
Physiological Reviews (Blalock) vol. 69. No. 1, pp. 1-33 (1989).
Journal f. prakt. Chemie. (Joshi, Dubey) Band 321, Heft 2, pp. 341-344 (1979).
Journal of Medicinal Chemistry (Springer, et al.) vol. 19, No. 2, pp. 291-296 (1976).
J. Heterocyclic Chem. (O'Brien, et al.) 22:601-634 (1985).
J. Med. Chem. (Senga, Novinson, Wilson) 24:610-613 (1981).
Science (Vale, et al.) 213:1394-1397 (1981).
Chemical Abstracts, vol. 67, No. 28, 1967, abstract # 108663r.
Chemical Abstracts, vol. 74, No. 28, 1971, abstract # 22867t.
Chemical Abstracts, vol. 74, No. 28, 1971, abstract # 22872r.
Chemical Abstracts, vol. 68, No. 28, 1968, abstract # 114635v.

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