Azole peptidomimetics as thrombin receptor antagonists

Details Azole peptidomimetics as thrombin receptor antagonists Azole peptidomimetics as thrombin receptor antagonists

1999-02-08

2000-01-25

Celsa, Bennett

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 18, 530330, 530331, 548146, 548215, 5483335, 5483351, A61K 3800, C07K 500

Patent

active

060178906

ABSTRACT:
Azole derivatives of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.

REFERENCES:
Bioorganic & Medicinal Chemistry Letters, vol. 8, No., 13, Jul. 7, 1998, pp. 1649-1654.
Database WPI Section Ch, Week 9601, Derwent Publications Ltd., London, GB Class B03, AN 96-006941 XP002103727 & JP 07 285952 A (Fujisawa Pharm Co Ltd), Oct. 31, 1995.
M S Bernatowicz et al."Development of potent thrombin receptor antagonist peptides" Journal of Medicinal Chemistry vol. 39, No., 25, Dec. 6, 1996, pp. 4879-4887,XP002095053.
Scarborough, R.M. etal. "Thrombin receptor antagonists derived from "tethered ligand" agonists Peptides" 1994, PEPT.: Chem., Struct. Biol. Proc. Am. Pept, Symp., 13.sup.th (1994) meeting date 1993, 695-7. Hodges, Robert S., Smith, John A. XP002103726.
"Azole endothelin antagonists. 1. A receptor model explains an unusual structure-activity profile." Journal of Medicinal Chemistry, (Feb. 16, 1996) 39 (4) 957-67, JOF ISSN: 0022-2623 XP002103725.

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