Azole-fused peptides and processes for preparation thereof

Details Azole-fused peptides and processes for preparation thereof Azole-fused peptides and processes for preparation thereof

1992-07-10

1995-01-03

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530321, 530328, 530329, 530330, 530331, C07K 508, C07K 510, C07K 512, C07K 706

Patent

active

053788036

ABSTRACT:
Azole-fused peptides useful as Substance P antagonists and analgesics, for example ##STR1## wherein ##STR2## represents ##STR3## wherein X is O, S or NH and * is D, or as intermediates therefor are prepared by azole and peptide forming methods.

REFERENCES:
patent: 4472305 (1984-09-01), Hansen et al.
Sandberg et al., J. Med. Chem., vol. 25, No. 9, pp. 1009-1015, 1982.
Pettit et al., J. Am. Chem. Soc., vol. 104, pp. 905-907, 1982.
Oikawa et al., J. Org. Chem., vol. 42, pp. 1213-1216, 1977.
Stork et al., J. Org. Chem., vol. 41, pp. 3491-3493, 1986.
O'Donnell et al., Tet. Let., No. 30, pp. 2641-2644, 1978.
Nakajima et al., Peptide Chemistry 1982, Protein Research Foundation, Osaka, Japan, pp. 19-24, 1983.

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