Azole derivatives, pharmaceutical compositions containing the sa

Details Azole derivatives, pharmaceutical compositions containing the sa Azole derivatives, pharmaceutical compositions containing the sa

1993-09-15

1995-04-18

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5482674, 5482678, 5482686, A01N 43653, C07D24908

Patent

active

054079527

ABSTRACT:
Azole derivatives (including stereoisomers and pharmaceutically acceptable salts) of the formula: ##STR1## wherein R.sub.1 and R.sub.2 each are H or C.sub.1 -C.sub.4 alkyl; R.sub.3 is H, OH, CN, halogen, haloalkyl, C.sub.1 -C.sub.4 alkyl or phenyl, and if there are two or more R.sub.3 groups, such R.sub.3 groups may be the same or different; n is an integer from 0 to 5; Y is N or CH; and X is O, S or NH have antimycotic and aromatase inhibitory activities. Compositions containing the azole derivatives and a method of treating mycosis and estrogen-dependent diseases by administering effective quantities of the azole derivatives are also disclosed.

REFERENCES:
patent: 4735960 (1988-04-01), Hirsch et al.

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