Azole derivatives

Details Azole derivatives Azole derivatives

1972-06-06

1976-01-20

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260243B, 2602471M, 2602475E, 260268C, 26029367, 26029368, 260302H, 260302S, 424246, 424248, 424250, 424267, 424270, 424272, C07D26346

Patent

active

039338401

ABSTRACT:
Azole derivatives of the formula ##SPC1##
Wherein R.sub.1 is free or esterified carboxyl or other functionally modified carboxyl group, R.sub.2 and R.sub.3 each are aryl; A is C.sub.n H.sub.2n in which n is an integer from 1 to 10, inclusive; and Z is O or S; and the physiologically acceptable salts thereof, possess, with good compatibility, excellent antiphlogistic activity and, in particular, influence favorably the chronic progressive diseases of the joints, e.g., arthritis. They can be prepared from compounds of the formula ##SPC2##
Wherein X.sub.1 is a group convertible into the group --S--A--R.sub.1, and R.sub.2 and R.sub.3 have the values given above.

REFERENCES:
patent: 2513923 (1950-07-01), Duffin et al.

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