Azole compounds, their production and use

Details Azole compounds, their production and use Azole compounds, their production and use

1996-05-01

1998-08-11

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5482678, 5483137, 5482666, 514397, A61K 3141, A61K 31415

Patent

active

057927804

ABSTRACT:
The present invention provides an azole compound represented by the formula (I): ##STR1## , wherein Ar is an optionally-substituted phenyl group; R.sup.1 and R.sup.2 are, the same or different, a hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 may combine together to form a lower alkylene group; R.sup.3 is a hydrogen atom or an acyl group; Y is a nitrogen atom or a methine group; and A is an optionally-substituted saturated cyclic amide group bonded through a first nitrogen atom, or a salt thereof, which is useful for prevention and therapy of fungal infections of mammals as antifungal agent.

REFERENCES:
patent: 4753957 (1988-06-01), Chan
patent: 5371101 (1994-12-01), Itoh et al.
Konosu et al., "Triazole Antifungals IV. Synthesis And Antifungal Activities of 3-Acylamino-2-aryl-2-butanol Derivatives", Chem. Pharm. Bull., vol. 39(10):2581-2589, Oct. 1991.

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