Azlactone-functional substrates, corneal prostheses, and manufac

Details Azlactone-functional substrates, corneal prostheses, and manufac Azlactone-functional substrates, corneal prostheses, and manufac

1992-06-24

1994-03-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 424426, 424427, 424428, 424429, 525 542, 525375, 623 4, 623 5, A61F 214, C08K 515

Patent

active

052925145

ABSTRACT:
Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth.

REFERENCES:
patent: 2714721 (1955-08-01), Stone, Jr.
patent: 4118531 (1978-10-01), Hauser
patent: 4304705 (1981-12-01), Heilmann et al.
patent: 4451619 (1984-05-01), Heilmann et al.
patent: 4485236 (1984-11-01), Rasmussen et al.
patent: 4528325 (1985-07-01), Ofstead
patent: 4612012 (1986-09-01), White
patent: 4613665 (1986-09-01), Larm
patent: 4618649 (1986-10-01), Ofstead
patent: 4655770 (1987-04-01), Gupta et al.
patent: 4673539 (1987-06-01), Hammar et al.
patent: 4715858 (1987-12-01), Lindstrom
patent: 4772283 (1988-09-01), White
patent: 4828563 (1989-05-01), Muller-Lierheim
patent: 4852969 (1989-08-01), Babirad et al.
patent: 4855234 (1989-08-01), Hendrickson et al.
patent: 4910277 (1990-03-01), Bambury et al.
patent: 4914223 (1990-04-01), Rasmussen et al.
patent: 4963494 (1990-10-01), Hibino et al.
patent: 4979959 (1990-12-01), Guire
patent: 5032131 (1991-07-01), Aysta et al.
patent: 5059654 (1991-10-01), Hou et al.
patent: 5064578 (1991-11-01), Insley et al.
patent: 5081197 (1992-01-01), Heilmann et al.
patent: 5108428 (1992-04-01), Capecchi et al.
patent: 5149806 (1992-09-01), Moren et al.
Wente, "Superfine Thermoplastic Fibers", Industrial Engineering Chemistry, vol. 48, pp. 1342-1346, (1956).
Wente et al., "Manufacture of Superfine Organic Fibers", Naval Research Laboratory Report #4364, 1954.
Tabata et al., "Immobilization of Callagen onto Polymer Surfaces Having Hydroxyl Groups", Biomaterials, vol. 7, pp. 234-238, May 1986.
Rasmussen et al., "Polyazlactones" Encyclopedia of Polymer Science and Engineering, vol. 11, John Wiley, pp. 558-571 (1988).
Trinkaus-Randall et al., "Development of a Biopolymeric Keratoprosthetic Material", Inv. Ophth. and Vis. Sci., 1988, vol. 29, pp. 394-400.
Kobayashi et al., "Covalent Immobilization of Proteins on to the Surface of Poly(Vinyl Alcohol) Hydrogel" Biomaterials, vol. 12, Oct. 1991.
Kobayashi et al., "Immobilization of Proteins onto PVA Surface" Translated from Abstract Presented at Meeting in May 1988 of Polymer Science Society of Japan.
Scouten, "Affinity Chromatography-Bioselective Adsorption on Inert Matrices" Chemical Analysis vol. 59, (John Wiley & Sons, N.Y.), pp. 48-49, 68-69, and 74-75 (1981).
STN International Abstract of Japanese Kokai JP 02070711 (1990) concerns benzophenone compounds.

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