Azlactone functional particles incorporated in a membrane formed

Details Azlactone functional particles incorporated in a membrane formed Azlactone functional particles incorporated in a membrane formed

1994-04-13

1995-12-19

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424485, 424486, 424487, 424488, 424 783, 4241941, 5147721, 521 27, 523336, A61K 926, A61K 900, A61K 31785, C08J 520

Patent

active

054766656

ABSTRACT:
A composite membrane is provided having covalently azlactone functional particles incorporated in a membrane formed by solvent phase inversion. The azlactone functional particles have surfaces of covalently reactive functional groups capable of directly forming covalent chemical bonds with ligands without need for an intermediate activation step. An adduct composite membrane is also provided comprising the membrane and derivatized particles dispersed therein. The derivatized particles comprise a direct, covalent reaction product of ligand with the covalently azlactone functional particles. Methods of making and using the composite membranes and adduct composite membranes are also provided.

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