Azlactone activated polyalkylene oxides conjugated to biological

Details Azlactone activated polyalkylene oxides conjugated to biological Azlactone activated polyalkylene oxides conjugated to biological

1994-03-30

1996-10-22

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 7838, 525 541, 530815, A61K 3177

Patent

active

055674224

ABSTRACT:
Water-soluble azlactone activated polyalkylene oxides having improved hydrolytic stability and conjugates of the azlactone activated polyalkylene oxides with biologically active nucleophiles are disclosed. Methods of forming and conjugating the activated polyalkylene oxides with biologically active nucleophiles are also disclosed.

REFERENCES:
patent: 4999417 (1991-03-01), Domb
patent: 5200471 (1993-04-01), Colgman et al.

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