Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1981-12-18
1987-11-03
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 3133
Patent
active
047043849
ABSTRACT:
The use of aziridinyl quinones as antitumor agents is disclosed. A compound which has been found to be particularly effective is the compound 2,5-diaziridinyl-3,6-bis (carboethoxyamino)-1,4-benzoquinone. Treatment is described in connection with various forms of leukemia, for example, as well as B16 melanoma, Lewis lung carcinoma, and the ependymoblastoma brain tumor system.
REFERENCES:
Investigational New Drugs 1:71(1983), Bender et al.
Curt et al., Can. Research 43, 6102-6105 (1983), vol. 43.
Chou Feng-Te
Driscoll John S.
Khan A. Hameed
Goldberg Jerome D.
The United States of America as represented by the Department of
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