Aziridinyl quinone anti-transplanted tumor agents

Details Aziridinyl quinone anti-transplanted tumor agents Aziridinyl quinone anti-transplanted tumor agents

1977-01-12

1979-03-27

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424856, 424250, 424274, A61K 3133, A61K 31535, A61K 31495, A61K 3140

Patent

active

041466225

ABSTRACT:
The use of aziridinyl quinones as antitumor agents against transplanted tumors in mice is disclosed. A compound which has been found to be particularly effective is the compound 2,5-diaziridinyl-3,6-bis (carboethoxyamino)-1,4-benzoquinone. Treatment is described in connection with several transplanted mouse tumor test systems including various forms of leukemia, for example, as well as B16 melanoma, Lewis lung carcinoma, and the ependymoblastoma brain tumor system.

REFERENCES:
patent: 2802001 (1957-08-01), Marxev
patent: 2913453 (1959-11-01), Petersen et al.
patent: 3211721 (1965-10-01), Marxev
patent: 3462531 (1969-08-01), Jaques et al.
patent: 3631026 (1971-12-01), Nakao et al.
Chou et al., J. of Med. Chem., 1976, vol. 19, No. 11, pp. 1302-1308.

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