Azidophenylcyanoguanidines as photoaffinity probes

Details Azidophenylcyanoguanidines as photoaffinity probes Azidophenylcyanoguanidines as photoaffinity probes

1994-06-10

1996-06-11

Cook, Rebecca

Organic compounds -- part of the class 532-570 series

Organic compounds

Azides

C07C27928

Patent

active

055257429

ABSTRACT:
This invention comprises novel compounds that are useful and effective as photoaffinity probes useful for the identification of the biochemical components that form K.sub.ATP channels in smooth muscle cells. The probes are described by the formula below, ##STR1## where R.sub.1 is H, C.sub.1-3 alkyl; R.sub.2 is H, C.sub.1-3 alkyl; or

REFERENCES:
patent: Re31244 (1983-05-01), Petersen
patent: 4057636 (1977-11-01), Petersen
patent: 5336689 (1994-08-01), Weber et al.
Mais, Dale E., et al., "Novel Synthesis and Biochemical Properties of an [.sup.125 I]-Labeled Photoaffinity Probe for Thromboxane A.sub.2 /Prostaglandin H.sub.2 Receptors," J. Med. Chem., 34, 4, pp. 1511-1514 (1991).
Petersen, Hans J., et al., "Synthesis and Hypotensive Activity of N-Alkyl-N-cyano-N'-pyridylguanidines," J. Med. Chem., 21, 8, pp. 773-781 (1978).

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