Azido-substituted aromatic amino acids

Organic compounds -- part of the class 532-570 series – Organic compounds – Azides

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C07C24716

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active

052761703

ABSTRACT:
Azido-substituted aromatic amino acids represented by the following formula I are synthesized through the use of tyrosine phenol-lyase. The azido derivatives are suitable for use as photoaffinity labels and inhibitors; ##STR1## wherein R.sup.1 represents a lower alkyl, a lower alkoxy, or an hydroxy group; R.sup.2 and R.sup.3 each independently represent a hydrogen or a lower alkyl group; X represents a hydrogen, a lower alkyl, an alkali metal, or an ammonium group; n is an integer of 0 to 3.

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J. Org. Chem., 1986, 51, 1175-1179, T. E. Walker et al.
Biotechnology and Bioengineering, vol. XXII, Suppl. 1, 127-161, (1980), Nobuyoshi Esaki et al.
Analytical Chemistry, vol. 59, No. 11, Jun. 1, 1987, pp. 1534-1538, Margaret E. Rice et al.

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