Azido derivatives of cyclopentane heptanoic or heptenoic acid

Details Azido derivatives of cyclopentane heptanoic or heptenoic acid Azido derivatives of cyclopentane heptanoic or heptenoic acid

1992-10-16

1994-07-26

Gerstl, Robert

Abrasive tool making process, material, or composition

552 10, 552 12, C07C24712, A61K 31557

Patent

active

053327306

ABSTRACT:
The present invention provides novel 2-aliphatic or arylaliphatic cyclopentane heptanoic and heptenoic acid derivatives including at least one azido substituent. In particular 2-aliphatic or arylaliphatic cyclopentane heptenyloic and cyclopentane heptanoic acids and esters thereof, substituted at the 3 and/or 5 position of the cyclopentane ring with radicals selected from the group consisting of hydroxy, azido and mixtures thereof, are disclosed. These azido compounds are useful as ocular hypotensives and are intermediates for the preparation of other compounds useful as ocular hypotensives.

REFERENCES:
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patent: 4994274 (1991-02-01), Chan et al.
patent: 5034413 (1991-07-01), Chan et al.
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Bito, L. Z., "Prostaglandins, Old Concepts and New Perspectives", Arch. Ophthalmol, 105, 1036, 1987.
Siebold, et al., "Esterified prostaglandin shows `potent` promise", Prodrug 5, 3, 1989.

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