Azetomicins

Details Azetomicins Azetomicins

1975-08-18

1977-10-11

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

195 29, 195 51R, 424177, C07C10352, A61K 3700

Patent

active

040534600

ABSTRACT:
Modified actinomycin compounds that incorporate azetidine in the polypeptide component of the actinomycin molecule are disclosed. These compounds are called Azetomicins and specifically incorporate an azetidine derivative in the 3' peptide position in at least one of the two polypeptides normally present in actinomycins. The Azetomicins are produced by bio-synthetic means from Streptomyces antibioticus that are cultured on a medium including azetidine-2 carboxylic acid and derivatives thereof.

REFERENCES:
hollstein: Chem. Rev. 75, 625-652 (1974).

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