Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1982-02-16
1982-10-05
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
2602393T, 2602393P, 260239A, 2603303, A61K 3155, C07D51322, C07D48714
Patent
active
043528163
ABSTRACT:
There is presented imidazodiazepines of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is the group ##STR2## R.sup.1 is hydrogen, lower alkyl, lower alkoxymethyl, halogen, nitro or a group of the formula --COOR.sup.4,R.sup.2 is hydrogen, trifluoromethyl or halogen, R.sup.3 is hydrogen, trifluoromethyl, halogen or lower alkyl, R.sup.4 is methyl, ethyl or isopropyl and X is an oxygen or sulphur atom and the carbon atom denoted as .gamma. has the (S)- or (R,S)-configuration, and their pharmaceutically acceptable acid addition salts.
The compounds are useful in the antagonization of the central-depressant, muscle relaxant, ataxic, blood pressure-lowering and respiratory-depressant properties of 1,4-benzodiazepines which have tranquillizing activity. They can also be used for suppressing the activities on the central nervous system of 1,4-benzodiazepines used in other fields of therapy, for example, of schistosomicidally-active 1,4-benzodiazepines. Also provided are methods to produce the above compounds.
REFERENCES:
patent: 4316832 (1982-02-01), Gerecke et al.
Hunkeler Walter
Kyburz Emilio
Bond Robert T.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Saxe Jon S
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