Azeto-imidazo-diazepines

Details Azeto-imidazo-diazepines Azeto-imidazo-diazepines

1982-07-30

1983-10-04

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602393T, 260239A, 424273R, C07D48712, C07D51222

Patent

active

044077521

ABSTRACT:
There is presented imidazodiazepines of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is the group ##STR2## R.sup.1 is hydrogen, lower alkyl, lower alkoxymethyl, halogen, nitro or a group of the formula --COOR.sup.4, R.sup.2 is hydrogen, trifluoromethyl or halogen, R.sup.3 is hydrogen, trifluoromethyl, halogen or lower alkyl, R.sup.4 is methyl, ethyl or isopropyl and X is an oxygen or sulphur atom and the carbon atom denoted as .gamma. has the (S)-- or (R,S)-- configuration,
and their pharmaceutically acceptable acid addition salts.
The compounds are useful in the antagonization of the central-depressant, muscle relaxant, ataxic, blood pressure-lowering and respiratory-depressant properties of 1,4-benzodiazepines which have tranquillizing activity. They can also be used for suppressing the activities on the central nervous system of 1,4-benzodiazepines used in other fields of therapy, for example, of schistosomicidally-active, 1,4-benzodiazepines. Also provided are methods to produce the above compounds.

REFERENCES:
patent: 4352816 (1982-10-01), Hunkeler et al.

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