Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-06-07
2005-06-07
Saeed, Kamal (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S408000, C546S268100, C548S950000
Reexamination Certificate
active
06903123
ABSTRACT:
Disclosed are nociceptin ORL-1 receptor agonists of the formulawherein:(a) R1is optionally substituted alkyl, fluorenyl, pyrimidinyl or optionally substituted piperidinyl;R2is H; and R3is —C(H)(R)—NR7R8;R is H, optionally substituted aryl or arylalkyl, or heteroaryl;R7is —(CH2)xR9, optionally substituted tetrahydronaphthyl, or cycloalkyl; and R8is H;or R7and R8together form a substituted piperidinyl or piperazinyl ring;x is 0-10; andR9is H, alkoxy, optionally substituted phenyl, naphthyl, heteroaryl, pyrrolidinyl, pyrrolidonyl, optionally substituted piperidinyl or diphenylmethyl; or(b) R2is —NHR7orand R3is H;pharmaceutical compositions; and methods of using the compounds to treat cough and pain.
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Burnett Duane A.
Caplen Mary Ann
Czarniecki Michael F.
Domalksi Martin S.
Ho Ginny D.
Magatti Anita W.
Saeed Kamal
Schering Corporation
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