Azetidinone N-phosphonomethyl esters

Details Azetidinone N-phosphonomethyl esters Azetidinone N-phosphonomethyl esters

1987-09-01

1989-04-11

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540363, 540364, 540205, 548112, 548406, 548413, 560170, 560169, 562564, 562567, C07F 965

Patent

active

048208159

ABSTRACT:
The invention provides azetidinones of the formula ##STR1## where R.sub.4 is hydrogen, amino or protected amino; R.sup.0 is H when R.sub.4 is amino or protected amino, or C.sub.1 -C.sub.4 alkyl when R.sub.4 is H; R.sub.1 is H, CH.sub.3, --CH.sub.2 --.sub.n Y where Y is OH, protected OH, --CH.sub.2 OH, protected --CH.sub.2 OH, halogen, COOH or protected COOH; n is 1 or 2; --CH.sub.2 --C(O)SR.sub.1 ' where R.sub.1 ' is e.g., C.sub.1 -C.sub.4 alkyl; R.sub.2 is H or protecting group and R.sub.3 is e.g., alkyl or phenyl. The azetidinones obtained are useful intermediates to carbapenems and carbacephems and monocyclic antibacterials, e.g., .alpha.-(dialkylphosphono)-[[3.beta.-[2-(2-aminothiazol-4-yl)-2-(syn)metho xyiminoacetylamino]azetidin-2-one-1-yl]]acetic acid and pharmaceutically acceptable salts thereof.

REFERENCES:
Derwent Abstract of Kyowa Hakko Kogyo, Japan Application No. J5 7091-991.
Herdewijn, Chem. Abs. 101, 38237z (1983).
Hirata, Chem. Abs. 93, 150115a (1978).

Affiliated with

Also associated with

Rating

Azetidinone N-phosphonomethyl esters does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Azetidinone N-phosphonomethyl esters, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Azetidinone N-phosphonomethyl esters will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-668149