Azetidinone derivatives, a process for their preparation and the

Details Azetidinone derivatives, a process for their preparation and the Azetidinone derivatives, a process for their preparation and the

1993-03-23

1999-01-05

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540200, C07D47700, C07D20508, C07F 9568, C07F 718, C07C33300

Patent

active

058565566

ABSTRACT:
Compounds of formula (I): ##STR1## (wherein R.sup.1 represents hydrogen or a hydroxy-protecting group, R.sup.2 and R.sup.3 represent hydrogen, alkyl or aryl; R.sup.4 represents optionally substituted alkyl, alicyclic heterocyclic, aryl, aromatic heterocyclic, optionally substituted alkenyl or optionally substituted alkynyl; R.sup.5 represents hydrogen or a carboxy-protecting group; and R.sup.6 represents alkoxy, aryloxy, dialkylamino or diarylamino or two or R.sup.6 together represent o-phenylenedioxy or three together represent CH.sup.3 C(--CH.sub.2 O--).sub.3) may be prepared by reacting the corresponding carbonyl compound with a compound of formula P(R.sup.6).sub.3. Compounds (I) may be cyclised to prepare carbopenem derivatives, many of which have valuable antibiotic activity.

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