Azetidines as MEK inhibitors for the treatment of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S248000, C514S252030, C514S252050, C514S256000, C514S318000, C514S403000, C544S235000, C544S242000, C544S333000, C544S405000, C546S208000, C546S210000, C546S268100, C546S268400, C546S275400

Reexamination Certificate

active

07915250

ABSTRACT:
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

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Shpiro, N. et al., “Improved Experimental Procedure for the Synthesis of the Potent MEK Inhibitor PD184352”, Synthetic Communications, vol. 35, 2005-2265-2269.

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