Azetidines

Details Azetidines Azetidines

1998-01-26

2000-02-08

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544121, 544130, 544360, 544364, 546200, 546201, 546202, 546205, 546206, 546212, 546219, 546220, C07D20502, C07D40102, C07D40114

Patent

active

060229713

ABSTRACT:
The present invention provides compounds of the formula (I): ##STR1## and the pharmaceutically acceptable salts thereof, wherein R is C.sub.3 -C.sub.7 cycloalkyl, aryl or C.sub.1 -C.sub.6 alkyl, said C.sub.1 -C.sub.6 alkyl being optionally substituted by fluoro, --COOH, --COO(C.sub.1 -C.sub.4) alkyl, C.sub.3 -C.sub.7 cycloalkyl, adamantyl, aryl or het.sup.1, and said C.sub.3 -C.sub.7 cycloalkyl being optionally substituted by 1 or 2 substituents each independently selected from C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.1 -C.sub.4 alkoxy, hydroxy, fluoro, fluoro(C.sub.1 -C.sub.4) alkyl and fluoro(C.sub.1 -C.sub.4)alkoxy;

REFERENCES:
Al-Tarakji-Khalfh et al., Mechanism of the Formation in vivo of alpha-phenyl-gamma-lactones in the Glutethimide Series, European Journal of Medicinal Chemistry, vol. 28, No. 7-8, pp. 593-600, 1993.
Smissman et al., Synthesis of 3-Keto-6-phenyl-8-methyl-9-oxa-delta 1.2-2-azabicyclo[4.3.0]nonane, Journal of Organic Chemistry, vol. 40, No. 3, pp. 281-283, 1975.

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