Azetidine derivatives to treat memory and learning disorders

Details Azetidine derivatives to treat memory and learning disorders Azetidine derivatives to treat memory and learning disorders

1988-06-24

1991-02-05

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61K 31395

Patent

active

049905040

ABSTRACT:
This invention relates to novel azetidines and derivatives thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and compositions as biological tools and materials for characterizing excitatory amino acid receptor systems. A further aspect of the invention relates to a method of treating PCP toxicity and abuse.

REFERENCES:
Wasserman et al, Tetrahedron Letters (1984) vol. 25:25, 3111-3114.
Baldwin et al, J. Chem. Soc. Chem. Commun, (1985) pp. 194-196.
Baldwin et al, Tetrahedron Letters (1986) vol. 42:17, 4879-1888.
Wroblewski et al, Proc. Natl. Acad. Sci (1987) vol. 84, pp. 5068-5072.

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