Azetidine derivatives, compositions and methods of treating

Details Azetidine derivatives, compositions and methods of treating Azetidine derivatives, compositions and methods of treating

1987-07-17

1990-08-07

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

548953, 548950, A61K 31395, C07D20504

Patent

active

049468391

ABSTRACT:
This invention relates to novel azetidines and derivative thereof, as well as to pharmaceutical compositions and methods of treating memory and learning disorders. Another aspect of the invention relates to a method of utilizing the compounds and compositions as biological tools and materials for characterizing excitatory amino acid receptor systems. A further aspect of the invention relates to a method of treating PCP toxicity and abuse.

REFERENCES:
Wasserman et al., Stereochemical Effects in the Reactions of N-Alkyl-4-Substituted Azetidine 2 Carboxylic Acids with Oxalyl Chloride, Tetrahedron Letters, vol. 25, No. 29, pp. 3111-3114, 1984.
Baldwin et al., Gamma Lactam Analogues, J. Chem. Soc. Commun., 1985, pp. 194-196.
Baldwin et al., Gamma Lactam Analogues of Carbapenicillanic Acids, Tetrahedron vol. 42, No. 17, pp. 4879-4888, 1986.
Wroblewski et al., Phencyclidine is a Negative Allosteric Modulator, Proc. Nat. Acad. Sci. U.S.A. vol. 84, pp. 5068-5072, Jul., 1987.

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